Xenical weight loss capsules contain some active substance, called Orlistat. Orlistat is a strong gastrointestinal lipase inhibitor. Xenical (Orlistat) capsules are used to fight against excess weight and obesity, combining with hypocaloric diet.
Xenical drug inhibits the activity of enteric, pancreatic and gastric lipases, by blocking the splitting of triglycerides in the bowel. Therefore, Xenical diet pills reduce the intensity absorption of monoglycerides and free fatty acids in the gastrointestinal tract.
Xenical is different from other anorexigenic drugs (Phentermine, Sibutramine) by that it does not affect functions in the central nervous system, and thus never suppresses the appetite.
Clinical pharmacology of Xenical capsules
he unique feature of Xenical is that it provides a significant decrease of body mass and maintains normal weight of a patient without negative effect on psychophysical functions of the body.
Usage of Xenical capsules helps to reduce the body weight, as well as to exclude the probability of concomitant diseases, such as:
- diabetes type II
- impaired glucose tolerance
Pharmacological action of Xenical takes place in lumen of the stomach and small intestines.
Mechanism of pharmacological action of Xenical is aimed at formation of a covalent bond with active serine site of pancreatic and gastric lipases.
Under the influence of the active substance Orlistat, inactivated enzymes are not able to split fats, incoming with food in form of triglycerides, monoglycerides and fatty acids. Only a small part of non-split fats is absorbed in the human body. Thus, fats that come in the body with foods are excreted out of the body unchanged.
Indication for Xenical use
Xenical is indicated for patients older than 12 and adults, for the treatment of class I,II,III and IV obesity. Xenical has to be combined with low-calorie diet. When using Xenical, one should have a clear well-composed diet plan.
The diet must be based on use of less amount of fats and larger amount of carbohydrates and vitamins.
Patients with diabetes mellitus (type II) are often prescribed Xenical diet pills in combination with hypoglycemic drug Metformin or Insulin.
Xenical dosage instructions
- Xenical capsules are only taken by mouth with meals, or within an hour after food intake.
- Maximum recommended dosage of Xenical drug to treat obesity – is 120 mg (i.e. one capsule of Xenical 120mg).
- Capsules Xenical 120mg have to be taken 3 times a day, with each main meal.
- In case patient missed a meal, or he ate some low-calorie food without high fat in it, the single dose of Xenical 120mg can be skipped.
- The daily dose of Xenical 120mg is optimal, since the exceeding of the recommended dosage of Xenical 120mg does not accelerate the therapeutic effect.
- Efficiency and safety of Xenical diet pills in pediatric practice, as well as in adult patients with liver and kidney dysfunction, have not been studied yet.
Xenical side effects
In most cases side effects of Xenical occur in gastrointestinal tract, caused by that fats are excreted out of the body unchanged. The most often Xenical side effects are oily discharges from the colon, flatulence, frequent urge to defecate, loose stool, scatacratia (fecal incontinence), steatorrhea and resistant abdominal pain.
The given Xenical side effects are dose-dependent, and tend to intensify with increased Xenical daily dose. With peroral intake of Xenical, the active substance Orlistat and other inactive ingredients of the drug do not penetrate into the blood flow, excreted within 3-5 days with feces.
If you made a decision to order postal delivery of diet pills Xenical online, but you have never taken the weight loss drug Xenical (Orlistat), please apply to our online pharmacist for a qualified consultation. You can buy diet pills Xenical (Orlistat) online and get our online pharmacist’s consultation from any country 24/7.
Almost all major online-retailers (including Walmart) offer for sale Xenical capsules at the same price. In the third quarter of 2015, Xenical cost is just over $ 173 per package on online pharmacies.
On online pharmacies, Xenical cost with insurance is much lower than Xenical cost without insurance.
For example, Xenical cost with insurance is just over $6 per pack (84 pills) in Australia. Uninsured Australians buy Xenical capsules at a higher price – $132 per package.
Despite the fact that many people in developed countries have health insurance, the vast majority of obese people are not insured. Therefore, millions of obese people are forced to buy Xenical without insurance at the highest cost.
Among all the countries in North, Central and South America, the highest Xenical cost is in Canada and the USA, and the lowest – in Brazil.
Where to buy Xenical?
If you want to buy cheap Xenical, you can order it on online pharmacy. The legal U.S. suppliers of Xenical sell these weight loss capsules by prescription only, but cheap Xenical can be available without a prescription at the international online pharmacies.
Before using Xenical, it is necessary to make a diet plan. Xenical without diet does not provide rapid weight loss. Therefore, diet plan should be regarded as an integral part of weight loss program, rather than a recommendation, which is not necessarily to perform.
During the whole period of using Xenical diet pills, diet plan can periodically be changed. When changing the diet plan, remember that Xenical prevents the absorption of no more than 30% of fats consumed with food.
Given the fact that Xenical is not able to block the absorption of 100% of fat, patients should follow a low-fat diet. Herewith, the consumption of fats should not be limited completely. After all, a small amount of fats is necessary to maintain a normal metabolism.
Various diet plans recommended for use with Xenical diet pills can be found in consumers’ reviews of this drug. Online pharmacies where Xenical diet pills are available for sale can provide information about different diet plans – absolutely free.
To buy Xenical online, only a few minutes are needed. However, those who, want to reduce the cost of obesity treatment, can compare Xenical price on different online pharmacies before to buy it.
Today, dozens of online pharmacies provide the opportunity to order cheap Xenical online without a prescription.
Herewith, buyers can choose free Xenical shipping by regular post or pay for services of Xenical express delivery (next day delivery).
When choosing the postal service, it is necessary to find out for which countries Xenical next day delivery is offered. Some online pharmacies guarantee Xenical fast delivery only in the USA, but others – only in the UK.
Where is Xenical available?
Obese people can find Xenical on online pharmacies or buy this drug at conventional pharmacy network.
Xenical is approved as an obesity treatment in more than 140 countries worldwide. Therefore, this drug is available for the vast majority of obese people, regardless of their region.
Most consumers of Xenical leave positive reviews on the effectiveness of this slimming medicine. However, to find positive reviews about Xenical price is unreal.
After all, Xenical is one of the most expensive Orlistat-containing drugs. Therefore, the fact that Xenical helps to lose weight and the fact that the obesity treatment with Xenical is very expensive are confirmed in consumers’ reviews.
How much is Xenical?
When buying Xenical with insurance in Australia, patients pay only a few cents for one Xenical 120mg dose. The price of a Xenical 120mg capsule without insurance may exceed $6. Therefore, the cost of one day of anti-obesity therapy with Xenical can reach $6 – 7.
Several years have passed since cheap Xenical generic drugs appeared at the international market. Therefore, on online forums, reviews about Xenical are gradually replaced by reviews about cheap Xenical generic drugs.
In 2016, generic versions of Xenical are commercially available under hundreds of trademarks. If you want to find reviews about Xenical generic drugs, find out under what trademarks they are sold in your region.
For example, on the UK forums, you can find reviews about Xenical and about cheap Xenical generic – Beacita 120mg capsules.
Xenical Side Effects
Xenical, as well as any other slimming pills, can cause some adverse events. Xenical provides its therapeutic effect in the digestive organs; and therefore the gastrointestinal side effects are the most common ones.
Xenical drug contains one active pharmaceutical ingredient – Orlistat, which partially blocks the function of the gastrointestinal enzymes, called lipases. After the use of this medication, the dissolution and absorption of fat in the stomach is prevented.
Xenical drug for overweight and obesity treatment removes from the body about 30% fat, consumed with food. Most side effects are associated with its mechanism of action.
When using Xenical weight loss pills, people may notice such adverse reactions as stomachache, oily or loose stool, frequent or uncontrolled defecation, flatulence and increase in the number of bowel movements.
Usually, Xenical side effects are not dangerous for health, yet they can cause minor problems and discomfort.
- Still, most people can take Xenical without having any adverse events.
The efficiency and safety of Xenical drug was confirmed by many large-scale studies. Therefore, this drug can be used for several years in a row. Most Xenical side effects occur at the very beginning of using the drug and disappear after a short time.
There are other negative reactions of Xenical that can persist for a long time. For instance, when people use Xenical diet pills, the absorption of some vitamins in the body is reduced quite often.
During the anti-obesity treatment with Xenical, it is recommended to take multivitamins, containing fat-soluble vitamins A, D, E, K and organic compound beta-carotene. People should take multivitamins before sleep or 2 hours after Xenical capsule.
In order to reduce the risk of gastrointestinal side effects, people should take one Xenical capsule three times a day with main meals. If food contains no fat, people may skip the capsule.
If side effects did occur causing discomfort, it is recommended to use similar drugs but containing fewer amount of Orlistat active substance. In the USA, obese people can buy Alli drug without prescription, which contains twice less active substance than Xenical.
Xenical Weight Loss Drug
In April 1999, the US FDA approved a new drug for weight loss. Xenical is a specific gastrointestinal lipase inhibitor, providing a prolonged effect. Therapeutic effect of this drug is carried out in the lumen of small intestine.
Xenical weight loss drug disturbs the breakdown of fat, which comes into the body with food. Because unsplit fats are not absorbed in the intestines and are excreted out of the body with feces, the amount of calories is reduced.
This exactly contributes to weight loss.
It should be added that Xenical acts in the intestines only and is never absorbed into the blood.
Xenical drug for body mass correction is produced in solid blue gelatin capsules. The capsule has a sign “Xenical120” on the body and “Roche” – on the cap. Each Xenical capsule contains 120mg of active substance – Orlistat and 240 mg of excipients in the form of pellets.
Mode of application and doses
Xenical is recommended to adults for anti-obesity therapy.
The therapeutic dose for adults is 1 capsule, three times a day. Xenical capsules should be taken during the main meals or no later than 1 hour after a food intake.
If you missed a meal or if your food did not contain fats, then you may skip Xenical intake. The treatment of elderly patients is carried out as usual and no dose adjustment is needed.
The therapeutic effect of this drug during the treatment of overweight in teenagers under 18 years old has not been established.
Contrary to expectations, an increase of Xenical therapeutic dose (over 360 mg a day) does not increase the therapeutic effect. In liver or kidney dysfunction, there is no need to change the daily dose of the drug.
This medication is prescribed for a long-term therapy of obesity in combination with a low-calorie diet.
Xenical slimming drug is successfully used for the treatment in people with type 2 diabetes. Xenical used in a complex with hypoglycemic drugs and hypocaloric diet allows patients to achieve good weight loss results.
Contraindications for use
Xenical is contraindicated for patients, suffering from cholestasia, syndrome of chronic malabsorption and those, who are hypersensitive to Orlistat or other components of the drug.
Pregnancy and breastfeeding
There is no clinical data about the impact of Orlistat on the fetus during pregnancy. Therefore, this drug must never be prescribed to pregnant women.
In addition, nursing mothers must not use this drug, because no clinical trials on Orlistat excretion with breast milk have been conducted.
Just as other anti-obesity drugs, Xenical can cause side effects. The most common side effects usually occur from the gastrointestinal tract.
These side effects are frequent urge to defecate, loose stools, flatulence, pain and discomfort in the abdomen and steatorrhea.
The side effects can become more intense if a patient does not keep a low calorie diet. Therefore, before the beginning of the treatment course, the doctor should inform his patients about potential side effects from the gastrointestinal tract.
Moreover, he should explain how to eliminate these side effects by means of proper nutrition and a balanced diet. Usually, the GIT side effects occur at early stage of the treatment course (first 3 months), herewith most patients did not have these side effects at all.
It happened that patients complained of headaches, damaged teeth and gums, upper respiratory tract infection, anxiety and dysmenorrhea. In addition, some patients had such side effects as allergic reaction, like rash, bronchial spasm and anaphylaxis.
Many side effects of the drug are known, but still new unpredictable adverse reactions may occur.
Sometimes, these side effects may develop due to the use of several drugs at a time.
Xenical drug can reduce the absorption rate of vitamin A, D, E, K and beta-carotene. Because of this, patients should postpone the intake of vitamins for 2 hours after using Xenical or take them before sleep.
Xenical can reduce the concentration of cyclosporines in the blood plasma; hence, if a patient uses Xenical and cyclosporine together, it is recommended to test the concentration of cyclosporine in the blood plasma.
To reduce the likelihood of drug interactions, it is recommended to take cyclosporine 2 hours before or 2 hours after the intake of Xenical medication.
When patients used Xenical and anti-epileptic drugs together, there were incidents of seizures.
Although, no direct connection between seizures and Xenical anti-obesity therapy has been established, doctors should carefully monitor a patient’s state because the number and severity of seizure attacks can increase.
Patients should avoid combining Xenical and Acarbose due to the lack of data on pharmacokinetic trials.
Xenical drug for body mass correction made a good showing in anti-obesity therapy and it was approved by national healthcare systems in Australia, Canada and Europe.
espite the high price of Xenical (Orlistat) drug in the USA, it is very popular among obese Americans. The group of potential buyers of Xenical (Orlistat) includes Americans who have contraindications to amphetamine-like anorectic drugs.
In reviews about Xenical (Orlistat), you will not find information on the fact that this drug causes anxiety, depression or other psychiatric side effects.
Therefore, after comparing the reviews about Xenical (Orlistat) 120mg capsules and CNS stimulants (including Phentermine 37.5mg), many Americans choose Xenical fat blocker.
Just as other safe diet drugs, Xenical is sold legally on online pharmacies. In order to buy Xenical (Orlistat) online, a prescription can be required, but you can find online pharmacies where these slimming capsules are available without a prescription.
If you decide to buy Xenical (Orlistat) on CVS, Amazon and other online stores, first of all make sure that this Orlistat-containing product can be delivered to the region you live before to place your order.