Obesity – is a chronic disease, occurring due to formation and accumulation of excessive fat tissue in the human body.
The risk group of obesity includes people, who lead a sedentary lifestyle and who do not follow a normal diet. Obesity causes may include also insufficient sleep, frequent stresses, endocrine disorders and genetic predisposition.
The excess weight is formed due to imbalance between incoming and expended energy throughout a day. It means that people with excess weight, spend less energy than consume in calories within a day. The discrepancy between expanded and incoming energy in the body, leads to that the excess calories are accumulated in the body in form of visceral and subcutaneous fat.
Excess weight increases the risk of concomitant diseases, including:
- cardiovascular disorders, gallbladder disease and endocrine disorders.
- In order to reduce the risk of complications, occurring with adiposity, one needs to keep a well-balanced diet and make exercises.
- It is recommended take some medications for the weight loss along with diet, to achieve greater efficiency. It is known that the most effective and safe medicine against obesity – is Orlistat (gastrointestinal lipase inhibitor).
- Orlistat is one of the few types of diet drugs successfully passed clinical trials in the US and Europe. The drug appeared on the pharmaceutical market in 1998 and as might be expected from any new weight management strategy, rumors of his prowess were greatly exaggerated.
- Orlistat fat blocker is intended for those people who are at high risk of complications because of extra weight. Orlistat in any case is not a panacea. This drug works only in conjunction with well-known to everyone changes in eating and exercise.
- As practice has shown, drug Orlistat is moderately effective to treat people really suffering from obesity. Herewith, gastric lipase inhibitor Orlistat does not to pose any serious health risks.
The Mechanism of Orlistat Action
Orlistat, whose brand name is Xenical, blocks an enzyme necessary for fat digestion. If complete blocking of fat absorption would be possible, these weight loss pills could be a dream of any obese person.
During treatment course with Orlistat, 30 percent of fats contained in food are temporarily accumulated in the intestines, and then they are excreted undigested. This mechanism of action prevents penetration and accumulation of fats in the body.
If to compare the mechanism of action of Orlistat fat blocker with the mechanism of action of appetite suppressant (e.g., Phentermine), then the first has a number of advantages:
- Orlistat does not affect the heart function, which is already weakened in the majority of obese people
- The fat blocker does not cause physical or psychological addiction
- Orlistat works well and very reliably, so it can be used for a long time.
Orlistat is classified as an anti-obesity drug of peripheral action. Such mechanism of action is safer for health and at the same time is a major cause of unpleasant side effects.
Orlistat adverse reactions include abdominal pain, bloating, rare episodes of fecal incontinence and other intestinal problems. It should be noted that weight loss pills Orlistat do not pose any serious health risks.
Most obese people know how hard to cope with recalcitrant obesity and they understand that risk of side effects should not be an obstacle for obesity treatment. In addition, most of Orlistat side effects occur at the beginning of treatment course, are mild and disappear on their own
Some skeptics believe that such mechanism of action as blocking of fat absorption cannot contribute to a significant weight loss and successful treatment of obesity. However, skilled health professionals argue that weight loss should be gradual without stress for the body’s metabolism.
From a medical point of view, a goal of obesity treatment is not achievement of ideal body weight. Help is necessary for people to achieve biologically acceptable weight at which they will not be at increased risk of cardiometabolic diseases
It is worth to pay attention to another aspect. Orlistat excretes fats from the body together with fat-soluble vitamins. In order to maintain a normal balance of minerals, Orlistat should be taken in combination with multivitamins.
Orlistat is considered anti-obesity drug of moderate effectiveness. However, until “magic» slimming pills appear, Orlistat will be one of the most commonly prescribed drugs for treatment of overweight or obesity.
Orlistat is one of the few anti-obesity drugs that can be found on shelves of the American stores. Before Orlistat has been approved by the FDA in 1998, obese Americans had only one option for medical treatment of overweight or obesity – appetite suppressants.
A specific inhibitor of gastrointestinal lipases Orlistat is available in the United States under the brand names Alli and Xenical. The suppliers of these weight loss pills are the largest pharmaceutical companies Hoffmann-La Roche and GlaxoSmithKline.
Xenical capsules contain 120mg of active substance and they are available by prescription only. Obese people can buy Alli 60 mg capsules without prescription; therefore, it is not surprising that this dosage is more often sold.
After the beginning of Orlistat marketing, some weight loss experts were quick to say that the fat blocker helps to lose only modest amounts of weight. Observations made during usual medical practice have established that regular use of Orlistat helps to lose 5 to 15 percent of the initial body weight.
Weight loss by 5-15 percent is not the most outstanding results. The same results can be achieved by means of appetite suppressants, herewith for a shorter time. However, Orlistat has some undeniable advantages that favorably distinguish it from other weight loss pills.
Orlistat is a peripherally acting drug that works only in the intestine
Drug blocks fat splitting, whereby they cannot be absorbed in the gastrointestinal tract and accumulated in the body. One-third of fats contained in food is excreted from the body naturally. The only disadvantage is that fat-soluble vitamins are excreted together with fats.
Orlistat does not increase blood pressure and does not affect the brain function
History of all, without exception, appetite suppressants are accompanied with information that they often cause physical addiction and / or raise in arterial blood pressure. During using Orlistat, do not worry about this. The drug works in the intestine, so side effects can be diarrhea, flatulence, and abdominal pain.
Orlistat is recommended for long-term treatment of obesity
Orlistat is the first and only anti-obesity drug that can be an integral part of long-term weight loss program. Efficiency and safety of Orlistat is confirmed by national regulators, weight loss experts and consumers’ reviews, so the drug is available in more than 50 countries around the world.
Recommendations for Orlistat use
For a more effective weight loss before and during a course of Orlistat use, it is recommended to use diet and exercise. It relates to the fact that these methods in complex help to quickly restore proper metabolism in the body. This improves the work of vital functions and promotes weight loss.
Physical activity contributes to a rapid conversion of calories into energy due to fat deposits in the body.
Due to sports therapy during Orlistat use, redox processes are also increased and cardiovascular, digestive and respiratory systems are improved.
Physical activity in combination with Orlistat use considerably reduces the risk of many diseases that accompany obesity.
Among them, type 2 diabetes and diseases of the cardiovascular system such as stroke, myocardial infarction and angina pectoris are particularly dangerous.
- However, the drug is not intended for the prevention of such diseases.
For the maximum efficiency of Orlistat, various methods of a balanced diet are also used. Compliance with a balanced and hypocaloric diets helps to regulate the amount, thereby fat absorption process is suspended.
Remember that some vitamins such as A, O, D and E are cleaved only in fats. When using Orlistat, absorption of these fat-soluble vitamins decreases, so they should not be used during food together with Orlistat drug, but before bedtime.
- During clinical trials, it was also observed an undesired influence of other types of drugs on Orlistat effects.
They include Cyclosporin immunodepressant, indirect anticoagulants such as Warfarin and some antiarrhythmics, such as Amiodarone. The use of these drugs during Orlistat therapy is recommended to discuss with the attending doctor.
Orlistat is not cleaved in the body and almost completely excreted via the intestine on the average 4 days after the intake. Thus, Orlistat side effects on the internal organs and vital functions are minimal.
Orlistat 120 mg
Orlistat medication to treat obesity not only reduces the body weight but also helps to maintain weight at achieved level, preventing the regain of body weight. Orlistat proves itself as effective and safe drug for obesity treatment, including diseases related to obesity: type 2 diabetes, hypertension, cardiovascular diseases and diseases of endocrine system.
Orlistat drug possesses pharmacological property to inhibit the activity of gastric and pancreatic enzymes, participating in the splitting of vegetable and animal fats, entering the gastrointestinal tract with food.
Taking into account that the body is not able to digest unsplit fats, the use of Orlistat diet pills helps to excrete fats from the body unchanged.
- In the treatment of III and IV degrees of obesity, Orlistat single dose is 120mg.
- Patients with III and IV-degree obesity are recommended to take one capsule Orlistat 120mg three times a day.
- Orlistat 120mg capsules can be taken with food, one hour before food or one hour after food.
- In obesity treatment, the most effective result is achieved when taking Orlistat 120mg capsules in combination with low-calorie, balanced diet.
- Food consumption, containing more than 30% of fat in combination with single dose Orlistat 120mg increases the risk of gastrointestinal side effects (diarrhea).
- When treating of III and IV obesity degrees, recommended duration of Orlistat 120mg capsules is six month.
Effectiveness of Orlistat drug
Use of maximum recommended dosage Orlistat 120mg three times a day helps:
- to reduce the mass of visceral and abdominal fat;
- to reduce the amount of free fatty acids and monoglycerides in the intestinal lumen;
- to reduce the ability of cholesterol to penetrate in the blood plasma;
- to increase tissue insulin sensitivity.
When treating III and IV degrees of obesity, results of clinical studies have proved that daily use of Orlistat 120mg capsules for 52 weeks contributes to:
- weight loss by 6,2%;
- decrease in plasma insulin level by 18%.
- Therefore, Orlistat drug not only reduces excess weight but also decreases the risk of obesity-associated diseases.
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The prevalence of obesity is constantly growing in the developed countries and it is a matter of great concern among health professionals. After removal Fen-Phen and Meridia from the pharmaceutical markets, interest of doctors with experience with obesity has focused on a new anti-obesity drug Orlistat.
Orlistat is the first and only inhibitor of gastric and pancreatic lipases. The mechanism of Orlistat action is aimed at preventing cleavage of dietary triglycerides. Due to this effect, absorption of monoglycerides and free fatty acids is limited
Orlistat fat blocker works effectively and safely. Due to its distinctive features, Orlistat can compete with anti-obesity drug Phentermine, which is a recognized sales leader in the United States for many decades.
Orlistat is classified as peripherally acting drug and has a number of advantages compared to Phentermine and other central acting drugs
Orlistat main advantages are:
- Sustained weight loss and reduction of unwanted inches
- Lack of cardiovascular side effects
- The FDA approval as part of long-term weight loss program.
Orlistat fat blocker helps not only to get rid of extra pounds, but also to improve cholesterol level, blood pressure and blood sugar level. These conditions are major risk factors for serious and most common diseases.
Before Orlistat (Xenical) has received the FDA approval in 1999, many people had contraindications to drug therapy of overweight or obesity. The fact that the central nervous system stimulants do not only suppress appetite, but also raise blood pressure and pulse rate.
This specific inhibitor of lipases operates in the gastrointestinal tract and has no effect on other body systems. Therefore, people with cardiovascular diseases can take Orlistat without increasing risk of severe cerebral circulation impairment and irreversible necrosis of heart muscle.
The main advantage of Orlistat is that this fat blocker is approved for long-term treatment of overweight or obesity. Prescription appetite suppressants should be taken no more than 12 weeks that explains high failure rate among people using this type of anti-obesity drugs
This fat blocker does not cause physical or psychological addiction, so people suffering from obesity can buy low doses of Orlistat (Alli) without prescription. The drug has a good cost-effectiveness ratio, eliminates risk of adverse effects and therefore has a great potential for successful weight loss.
Popular Orlistat Brands
Aslene is one of the most popular anti-obesity drugs in Hong Kong. Aslene review will allow learning about the distinctive features and use of this drug.
Orslim drug is classified as a specific inhibitor of gastrointestinal lipases, which prevents fat absorption in the stomach. Orslim is prescribed to adult people diagnosed with overweight and obesity
Alli® (orlistat 60mg capsules) is for weight loss in overweight adults, 18 years and older, when used along with a reduced-calorie and low-fat diet. Learn more about Alli.
Oliet drug of peripheral action contains active substance Orlistat and it is used to manage chronic weight. During Oliet use, 30% of fat contained in the food consumed is derived from the body.
Aliduet is a drug to reduce and correct the body mass, which is produced by Mexican pharmaceutical company – Laboratorio Rimsa. The drug is prescribed for adults and adolescents over 12 years old.
Figurin (Orlistat) should be taken three times a day, just before each main meal. If you miss a meal or the meal contains no fat, you should also skip the intake of gastrointestinal lipase inhibitor Figurin. The recommended single dose of Figurin (Orlistat) is 1 Figurin 120mg capsule.
Redicres drug is prescribed to adolescents over 12 years and adult patients in the treatment of obesity and overweight. Weight loss drug Redicres is supplied by the Venezuelan pharmaceutical company Letifem in capsules at two dosages.
Zerotex (Orlistat) is a drug with a peripheral mechanism of action, which stops the absorption of fats in the gastrointestinal tract.
Orlistat in treatment of adiposity
Anti-obesity drug Orlistat can suppress the activity of gastric and pancreatic enzymes, splitting fats in gastrointestinal tract. Due to violated process of splitting fats, the rate of absorption fats from gastrointestinal tract is decreased. Systematic use of Orlistat provides decrease in body weight, regardless of obesity severity.
Orlistat and cardiovascular problems
Modus operandi of Orlistat can lead to unpleasant side effects, but usually they are mild and transient. It is important that unlike appetite suppressants, Orlistat does not affect the heart. The most common side effects of the fat blocker are abdominal pain, bloating and diarrhea.
Orlistat blocks absorption of fats in the gastrointestinal tract and fat is excreted in the feces. Therefore, side effects of Orlistat are explained by changes in activity of digestive enzymes
People do not want to experience side effects of weight loss drug Orlistat even if they are insignificant. Typically, control of fatty food intake helps to minimize risk of side effects.
Orlistat dosing for the treatment of obesity
- For I-II class obesity, the initial dose of Orlistat – is 60mg (one capsule of Orlistat 60mg).
- Orlistat 60mg capsules have to be taken three times a day, before or soon after meals.
- The intake of another dose of Orlistat 60mg can be skipped, if food does not contain fats (or you missed your meal).
- When taking Orlistat 60mg, the foods must contain under 30% of fats, not more. The less fat you take with food, the less Orlistat side effects you will have.
- The recommended duration of use of Orlistat 60mg capsules during the therapeutic treatment of I and II class obesity – is 6 months.
- The maximum recommended daily dose of Orlistat for patients with I and II class obesity – is 1800mg (which is three Orlistat 60mg capsules).
Orlistat is one of few medications, which can be prescribed for the treatment of adiposity not just in adults, but pediatric patients over 12 years old. Children over 12 years old do not require special adjustment of Orlistat daily dose.
Orlistat capsules should be taken only in conjunction with a weight loss program. The main elements of weight loss programs are a hypocaloric diet and moderate physical activity.
Orlistat diet capsules are recommended to be taken three times a day during meals.
If Orlistat was not taken simultaneously with the food, you can take it one hour after a meal.
Orlistat inhibits fat absorption from the gastrointestinal tract, so if the meal was missed or the food contains a minimum number of (no) animal and vegetable fats, a single Orlistat dose can be skipped.
If a person forgot to take capsules Orlistat, he may take it any time, if food intake took place not more than 1 hour ago.
If more than 2 hours passed after a meal, it is recommended to skip an Orlistat dose. During this time, most of the fat, ingested with food, has been already digested by the body, and Orlistat will not have a therapeutic effect.
Double Orlistat dose will not increase Orlistat therapeutic effect.
Compensating for the missed dose with a double Orlistat dose is not recommended.
Orlistat reduces the absorption of some fat-soluble vitamins.
- Therefore, for their sufficient quantity in the body, people taking Orlistat, are simultaneously prescribed multivitamin drugs, containing fat-soluble vitamins. A, D, E, K vitamins and beta-carotene are advised to be taken 2 hours before or after Orlistat capsules intake.
- Prescription Orlistat weight loss drug is taken as one Xenical 120mg capsule three times a day. The maximum allowable daily Xenical dosage is 360mg (three Xenical 120mg capsules).
- If Orlistat OTC is used for weight loss, then you should take one Alli 60mg capsule with each meal. The maximum allowable Alli daily dosage is 180mg (three Alli 60mg capsules).
- Taking Orlistat in dose, exceeding the maximum daily dosage (Xenical 360mg or Alli 180mg) does not increase the therapeutic effect. However, it increases the risk of side effects. Exceeding the maximum Orlistat daily dosage is contraindicated.
- During the Orlistat obesity treatment, metabolic control of diabetes improves simultaneously with weight loss.
Increase of tissue insulin sensitivity helps to reduce the daily dosage of hypoglycemic drugs (derivatives of sulfonylureas, Metformin or insulin).
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Orlistat drug, unlike other weight loss drugs, has few contraindications:
- Hypersensitivity to Orlistat or other drug ingredients;
- Chronic malabsorption syndrome;
- Pregnancy and lactation;
- Pediatric age to 12 years;
- Elderly age over 65 years.
Use of Orlistat capsules in people with hypersensitivity to the drug ingredients may increase the risk of side effects: rash, itching, abdominal pain, fecal incontinence and other gastrointestinal disorders.
Orlistat obesity therapy in people with malabsorption syndrome, enhances clinical manifestations (diarrhea, steatorrhea, polyhypovitaminosis, weight loss), which develop as a result of small intestine digestive and transport malfunction. Inability to absorb food and nutrients contributes to pathological changes in metabolism.
Before taking Orlistat weight loss drug, it is recommended to inform your doctor about any changes that are present at the moment.
For example, itching, change in urine or feces, can be cholestasis symptoms.
This condition is characterized by the reducing of bile amount entering duodenum. The flow of bile can be reduced due to disorders in bilification or bile flow.
The FDA ranked Orlistat to category X of drug influence on fetus.
Pregnant women were not involved in the Orlistat efficacy and safety research. The studies were conducted only in animals and showed possible fetal abnormalities. It is not known if Orlistat is released in breast milk. Therefore, Orlistat use in pregnancy and lactation is contraindicated.
Orlistat pregnancy and lactation
The FDA attributed Orlistat drug to category X during pregnancy. Taking category X drugs before and during pregnancy is contraindicated.
In clinical studies in animals given high Orlistat doses, were not revealed evidence of teratogenicity and embryotoxicity.
Pregnant women did not participate in Orlistat safety and efficacy clinical studies.
Given that there is no controlled data on Orlistat effect on human pregnancy, Orlistat is contraindicated in this period.
Orlistat use during pregnancy has adverse effects on fetal development and uterus function, exacerbates the gestation course.
Teratogenic Orlistat effect is the most dangerous, being characterized by the fetus congenital abnormalities development.
Since weight loss does not imply potential benefits for pregnant women and can cause harm to a fetus, Orlistat is contraindicated during pregnancy.
Women of reproductive age, while taking Orlistat, are recommended to use effective contraception methods. If pregnancy happens during Orlistat use, it is recommended to stop taking this weight loss drug and seek medical advice.
- Nursing mothers did not take part in Orlistat research.
Therefore, there is no clinical data on Orlistat excretion in breast milk. Since Orlistat use can harm the baby, its use during lactation is contraindicated.
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- Children and elderly people did not participate in clinical studies.
- Orlistat efficacy and safety in children and the elderly is not known.
Therefore, using the drug is contraindicated in children under 12 and people over 65 years. It should be noted that Orlistat Xenical is allowed for use in the pediatric age over 12 years. Alli Orlistat drug is prescribed to adolescents over 16 years of age.
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Side effects of Orlistat
Orlistat – is a powerful drug for obese people, which helps to lose excess weight. The mechanism of action of this drug is distributed exclusively on the gastrointestinal tract and does not affect the functions of other internal organs.
Orlistat reduces fat absorption by the body from food consumed. Just as any other drug, Orlistat may cause side effects.
The terms “adverse reactions” and “side effects” are generally interchangeable.
However, physicians use the term “adverse reactions” implying the patient’s response to a particular drug, but “side effects” is a result of the drug action on the patient’s body.
Since, Orlistat affects only the digestive system, main side effects occur mainly in the gastrointestinal tract, i.e. have exclusively local in nature. The negative impact of Orlistat is associated with pharmacokinetic mechanism of the drug preventing the absorption of fats from foods.
Very often, there are such side effects as oily discharge from the rectum, pain and discomfort in the stomach and loose stools.
Herewith, Orlistat is not toxic, since it does not destroy the intestinal mucosa.
In addition to the digestive system, Orlistat extremely rarely, but may cause side effects affecting other body systems. For example, headaches, respiratory tract infections and hypoglycemia may often occur.
Severe form of Orlistat side effects, such as nausea or vomiting is practically not observed in patients with obesity. When taking the drug, all negative reactions are mainly mild and do not cause much discomfort in the patient.
While using Orlistat, all adverse reactions of the body are mainly transient and their frequency is usually reduced in the second year of treatment in obese patients.
All side effects of Orlistat are manifestation of mechanism of action of the drug on the patient’s body, so they do not cause any harm to health.
Orlistat Drug Interactions
Orlistat may alter pharmacological effects or pharmacokinetic parameters of some drugs. Drug interaction manifests when taking Orlistat with such drugs. Simultaneous Orlistat use with some drugs can lead to drugs action intensification, as well as to the advent of Orlistat toxicity or both drugs.
Orlistat and Cyclosporine
Data from Orlistat and Cyclosporine interaction studies indicate that the simultaneous use of these drugs lowers plasma Cyclosporine levels. Therefore, Cyclosporine and Orlistat should not be taken simultaneously. Cyclosporine is recommended to be taken 3 hours after Orlistat intake.
- Orlistat and fat-soluble vitamin supplements and their analogues.
Pharmacokinetic interaction studies have shown that the use of Orlistat reduces the absorption of beta-carotene supplements. Orlistat also slows the absorption of vitamin E. Orlistat interaction with the absorption of A, D and K vitamins supplements are not known. Vitamins A, D, E, K and beta-carotene are advised to be taken 2 hours before or after Orlistat capsules intake.
Orlistat and Levothyroxine
Post-marketing studies have shown that the simultaneous Orlistat and Levothyroxine use increases the risk of hypothyroidism.
Therefore, people taking Orlistat in combination with Levothyroxine drug are recommended to control changes in thyroid function.
If Levothyroxine cannot be canceled for the period of Orlistat use, then these drugs should be taken separately. Make at least a 4-hour pause between Orlistat and Levothyroxine intake.
Orlistat and Warfarin
During Orlistat obesity treatment, people who are assigned for long-term Warfarin use, are recommended to monitor changes in blood clotting. Orlistat reduces the therapeutic effect of Warfarin (inhibits the synthesis of vitamin K-dependent coagulation factors and anticoagulant proteins C and S in liver).
Orlistat and hypoglycemic drugs
Weight loss during the obesity treatment with Orlistat can have a positive impact on glycemic control in people with diabetes. Therefore, during the Orlistat therapy some patients may need to decrease dosage of oral hypoglycemic drugs.
As with any other weight loss drugs, there is a potential for dependence development while using Orlistat.
The risk of Orlistat drug dependence is highest in people with anorexia nervosa or bulimia.
Before buying Orlistat online, check out the full information about its drug interactions. If you decide to buy Orlistat 60mg pills or Orlistat 120mg pills, but have never taken them before, consult a pharmacist.
Orlistat In Countries
- Bosnia and Herzegovina
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Orlistat Without Prescription
Orlistat is a number one weight loss drug approved for use in adults in more than 50 countries around the world. Orlistat, under the brand name Xenical, appeared in the USA in April 1999 and quickly became one of the sales leader.
- Xenical 120mg capsules by Hoffmann-La Roche are intended for people who do suffer from excess fat
- Due to the fact that Orlistat drug is recommended for long-term use; it has become the basic pharmacological support for standard scheme of weight control
- Orlistat fat blocker works in the intestines and has no significant effect on functions of other body systems
- Therefore, unlike other anti-obesity drugs, Orlistat does not cause small, medium or large cardiovascular problems
- A pharmaceutical company GlaxoSmithKline has analyzed consumers’ interest in Orlistat, has taken into account risks of side effects and has appealed to the FDA with a proposal to approve sale of Xenical generic drugs without prescription
- FDA reviewers evaluated this situation and initially were skeptical of such a proposal
- Later more information about using low doses of Orlistat and possible side effects was studied that has affected the final decision.
In February 2007, the FDA approved Alli (Orlistat) for sale without prescription. A distinctive feature of Alli is that it contains two times less amount of active substance than Xenical. Low content of active substance practically fully eliminates risk of moderate or severe side effects.
Just as Xenical, Alli blocks absorption of fat in the body by preventing breakdown of fat molecules. Both drugs should be taken before, during or immediately after eating. No more than three pills should be taken per day.
Health experts believe that attractiveness of Alli 60 mg capsules for treatment of severe obesity is lower than that of Xenical 120mg capsules. However, if to consider that most people suffer from overweight or mild obesity, we can explain why popularity of OTC doses of Orlistat 60mg has increased sharply.
In order to buy Orlistat 120mg diet pills, a doctor’s prescription is required. Getting of prescription may take a lot of time. Furthermore, additional medical examination can be recommended. Although, this procedure will not be superfluous in case of some diseases of the intestine
Supporters of OTC diet pills Alli believe that this drug is not only safe, but also cheap alternative to Xenical. This is true, especially if to take into account that there are no other Orlistat-containing drugs at the US pharmacies.
Another situation has developed in the EU. The European manufacturers of Orlistat 60mg and 120mg capsules are dozens of pharmaceutical companies that seek to occupy their niche at the market. High competition on the market of weight loss products led to a sharp decrease in prices on Orlistat-containing drugs
However, the cheapest generic drugs Alli and Xenical are manufactured and shipped from India. For many years, this country holds a leading position in the pharmaceutical industry and offers qualitative and safe generic drugs of Orlistat at the lowest prices.
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Retail sales of Orlistat capsules were launched over 15 years ago, and today you can buy them in dozens of countries, including the North and South American countries , the European countries, Asia-Pacific countries and Africa.
Two dosage forms of this weight loss product are supplied at the international pharmaceutical market.
- Orlistat 60mg capsules
- Orlistat 120mg capsules.
Orlistat 60mg capsules are sold at pharmacies without a prescription. Therefore, almost any person suffering from obesity can use them as over the counter weight loss aids.
Although Orlistat 60mg caps are sold without a prescription, patients who have never taken Orlistat fat blocker should learn its side effects, dosage, effectiveness, reviews and success stories that are published on various blogs and online forums.
Orlistat 120mg capsules are sold at urban pharmacies by prescription only. However, some international online pharmacies provide the opportunity to buy Orlistat 120mg capsules online without a prescription.
Orlistat 120mg capsules price on online pharmacies may differ from the price at usual pharmacy chains.
It should be noted that the cheapest Orlistat capsules are manufactured by Indian pharmaceutical companies that legally supply weight loss products to all developed countries.
Cheap Orlistat capsules are commercially available under various trademarks, such as Lipophage, Slim Trim Active, Zerofat and many others.
In our reviews, you can find information about the brands of Orlistat 60mg and 120mg capsules approved for weight loss in your home country.
When comparing Orlistat pills by different manufacturers, potential customers compare their price. When comparing Orlistat price, pay attention to the dosage of Orlistat fat blocker in a capsule or tablet, and to the number of Orlistat caps and tabs in a package.
To compare prices of Orlistat in different regions of the world, it is necessary to know under what generic names Orlistat-containing drugs are sold in different countries. Information on more than 150 different generic names of Orlistat can be found in our reviews.
- New manufacturers of Orlistat monthly appear at the pharmaceutical market.
Therefore, competition at the market of Orlistat-containing drugs is constantly increasing and retail price of Orlistat is decreasing at the global market.
It should be noted that the prices of Orlistat pills produced by the same company could be different in different pharmacies and online stores.
For example, Orlistat price is $0.58 cents per pill on Walgreens, but on Walmart, Orlistat price is $0.46 cents per pill. On Walgreens and Walmart, Orlistat pills are sold only under the brand name Alli.
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Orlistat sales leader
Despite Orlistat is classified as anti-obesity drug of moderate efficiency, its popularity increases progressively year by year.
- Obese people who are trying to lose weight have a very high failure rate, therefore small but constant weight loss is inspiring
- Orlistat is not a drug for rapid weight loss
- Unlike appetite suppressants, Orlistat is recommended for long-term use
- Due to its properties, Orlistat can become an integral part of any, even the most prolonged weight management plan
- Obese people can buy Orlistat in any country of the world
- A huge number of pharmaceutical companies produce and supply fat blockers, so price on weight loss pills Orlistat may vary.
An undeniable advantage is that obese people can officially buy Orlistat 60mg pills without prescription. The lowest prices on Orlistat pills can be found on online pharmacies or large pharmacy chains.