Yes, you found the ultimate guide on Duromine. We’ve studied all clinical trials, online Duromine reviews and doctors’ opinions & recommendations, and compiled this huge article.
It comprises the answers to all questions related to this Phentermine-containing weight loss drug.
During our thorough research, we noticed that some questions are more burning, and decided to help you find the answers to them ASAP without having to read all info that you might not need at the moment.
Now, if you’re here to learn everything about this medication, just keep on reading…
What is Duromine
Duromine is a weight loss product, produced by the pharmaceutical company iNova in the form of capsules for oral intake.
Available strengths are 15mg, 30mg and 40mg.
Milligrams indicate the amount of the anorexic agent Phentermine (as ion-exchange resin complex) in one Duromine capsule.
In addition to the active ingredient, each capsule contains inactive pharmaceutical ingredients (excipients: lactose, gelatin, liquid paraffin, stearate, magnesium, iron oxide black and titanium dioxide).
Besides the listed excipients, each capsule contains:
- 15mg – food colorings iron oxide yellow and brilliant blue FCF.
- 30mg – food coloring iron oxide red.
- 40mg – food colorings erythrosine and sunset yellow FCF.
You may ask, why do I need all thi information?
Well, knowing each and every ingredient that the drug contains is essential for a successful treatment, especially if you have known allergies.
Important information about the active ingredient of Duromine
As already mentioned, the active pharmaceutical ingredient of these slimming pills is Phentermine, and this agent is a CNS stimulant.
Therefore, in urban pharmacy chains Duromine (Phentermine) medication is only available under prescription.
Phentermine-containing medications are available on the market for almost 60 years now and multiple clinical trials have proven their efficiency for weight loss programs.
The active ingredient of starts acting by stimulating specific neurotransmitters responsible for appetite.
As a result, you don’t feel ravenous hunger and are capable of fighting cravings amd night-time binging.
There is one more thing important to know about Duromine: this drug also helps to burn the stored fat tissue.
Due to complex compound – Phentermine combination with a special resin – the release of the active substance is slowed down.
This effect contributes to appetite suppression throughout a day.
Do I need a prescription for Duromine?
Yes, you do!
Unfortunately, obesity maintains the leading position among chronic ilnesses not just in the USA, but all over the world.
If you didn’t know, this condition is severe for people whose weight is dangerously high.
So, if you already feel that your weight makes your life hard, but none of weight loss efforts that you made previously resulted in success, you do need assistance of a doctor, who should:
- Prescribe Duromine
- Provide recommendations on eating and exercising
- Monitor your progress and make necessary adjustments.
Yes, you do need a doctor to monitor your health, because Duromine is a strong medication, so avoid using the drug without a proper medical consultation.
At that, you need to understand that this drug does not have a magic effect.
Even though it improves your weight loss rate, you still need to make efforts to achieve considerable results.
Ok, the logic question is why do I need Duromine, if I still have to exercise and torture myself with diets?
It is not that simple…
The point is that Duromine diet pills work by suppressing your hunger.
Once you eat less, your body has to take the energy from somewhere else.
Thus, the drug also helps to burn fat (changing it into energy).
The good thing about Duromine is that you can start losing weight whenever you want.
These diet pills begin acting after the initiation of the treatment course.
It means that you don’t have to plan your lifestyle for months in advance.
Since the anti-obesity course lasts several weeks, it is a perfect time to get used to a new diet and exercise schedule.
In simple words, these slimming pills suppress appetite by influencing the brain receptors.
You might have seen this drug named as appetite suppressant and it is considered the best way to lose weight so far.
Keep in mind!
You should never use several appetite suppressants at a time, so avoid adding other drugs to the course, even if you want to see faster results.
Since there are many reviews and common data on these diet pills on the web, you might be confused what to believe in and how to get the best result with Duromine.
First, let’s see what effects the drug provides over your body.
Duromine effect on metabolism
Since the diet pills increase the blood circulation, they also increase fat metabolism in adipose tissue.
By suppressing appetite and enhancing fat metabolism, Duromine stimulates weight loss.
Hence, the weight loss might change the blood glucose level.
Therefore diabetic patients, who use these pills, might need to change the daily dose of hypoglycemic medications and (or) insulin.
Duromine effect on the central nervous system (CNS)
Duromine is among few stimulants of the CNS with an anorectic effect.
Acting on the CNS, it not only suppresses the appetite, but also improves wakefulness.
Namely because it increases the wakefulness, it is NOT recommended for use in the afternoon and before sleep.
If you take a Duromine dose in the evening, you might end up with bad sleep or even insomnia.
Duromine effect on liver and kidneys
The active ingredient of Duromie (Phentermine), which is partially metabolized in the liver, is excreted mostly by kidneys.
In liver dysfunction, you will not require individual adjustment of the daily dose.
In renal dysfunction, however, it is recommended to use the lowest possible daily doses.
Duromine effect on pregnancy
Pregnant women have not been involved in clinical studies of the anorectic agent.
However, it is known that Phentermine penetrates through the placental barrier, thus may affect the intrauterine development of the fetus.
Therefore, Duromine must never be prescribed as means to cope with excess weight in pregnancy.
If you are a woman of childbearing age, it is recommended to use reliable birth control agents during the use of these diet pills and have a negative pregnancy test before you take the first pill.
Duromine effect on male reproductive function
Duromine pills may cause poor libido or erectile dysfunction in men.
The highest daily dose increases the risk of erectile dysfunction.
However, this one is a reversible side effect of Duromine.
Therefore, male sexual ability is restored once the drug therapy of obesity is over, and men can continue with their normal sex life.
Does Duromine really work?
All availbe doses are equally effective in fight against excess weight.
As already mentioned, many clinical studies have shown that Duromine can reduce excess pounds even in most severe cases.
At that, participants to the trials followed a healthy diet and an active lifestyle.
The weight loss resultsof those, who adhered to the weight loss program with Duromine were higher than those, who dieted and exercised without taking the drug.
Duromine dosage depends on the age and severity of obesity, as well as presence or absence of concomitant risk factors.
Before prescribing an optimal daily dose, your doctor may schedule medical examination.
Please note that you might need the dose adjustment during the anti-obesity course.
Duromine dosage and teenage obesity treatment
Children of 12 to 17 years old are recommended to begin the obesity therapy with minimal Duromine dose of 15mg.
If the lowest daily dosage does not provide the anticipated anorexic effect, it can be increased up to 30mg.
Regardless of the severity of teenage obesity, the highest recommended dosage for children aged 12 to 17 is 30mg.
Higher daily doses of Duromine should only be taken by teenagers under the supervision of a doctor.
Duromine dosage for obesity treatment in adults
Initial daily dose of Duromine for adults is 30mg.
5-7 days after the initiation of therapy, the daily dosage can be increased to 40mg.
Adults can start taking Duromine 40mg capsules only if the lower dosage does not cause severe side effects.
In case it does cause severe side effects, the daily dosage must be reduced to 15mg.
Duromine dosage for the treatment of obesity in geriatric patients
For the initial stage of obesity therapy in the elderly patients, the daily dose of Duromine must not exceed 15mg.
7-10 after the initiation of the weight loss course, the daily dosage can be increased to 30mg.
In case the increased dosage causes side effects, immediately reduce the dose back to 15mg.
Elderly patients with renal dysfunction are at higher risk of side effects, compared to patients with a normal function of kidneys.
Changing Duromine dose regimen
During a the anti-obesity therapy, you might need to reduce the daily dose of the slimming drug.
Duromine dose changing is required when:
- You need to take one or more medications at once.
- Severe side effects manifested after the intake of Duromine capsules.
- Single daily dose, taken in the morning affects the nighttime sleep or causes insomnia.
Inform your doctor about any changes of Duromine dose regimen.
If you miss a dose, stick to your usual dosing schedule and never take double dose of this weight loss product.
A little more about different doses of Duromine…
Where a 15 mg cap does not provide a day-long effect, you may try to take two pills as a single 30mg dose, or take one 15 mg cap in the morning and another before midday.
The interval between the intakes of 15mg pill should be at least 4-6 hours.
The second dose of Duromine 15mg should be taken at least 8-10 hours before bedtime.
If sleep quality deteriorates or you suffer from insomnia, you have to change the dosing regimen.
Do not forget that even the minimal dose of Duromine 15mg can pose a potential threat to the general health.
So don’t forget that severe side effects require immediate cessation of the drug.
Duromine 30 mg
The manufacturer recommends this strength as a starting dose with further dose adjustment.
So, 30 mg is the most frequently prescribed Duromine dose.
Some overweight Australians take Duromine 30mg capsules for purposes other, than intended.
On different online forums and medical magazines, you may find information that truck drivers and students use Duromine 30mg capsules for better concentration on the road and during exams.
It often happens that people abusing the drug become hyperactive, hectic and irritable.
Please note that drug recreational use of Duromine is not recommended, especially due to possible dependence in uncontrolled use of this CNS stimulant.
However, this fact does not affect the effectiveness of the drug.
Because people, who use Duromine (Phentermine) do not feel hungry, regardless of the severity of drug dependence symptoms.
Single dose of Duromine 40mg can be taken only once a day.
If the desired weight loss is not reached within 3 months of regular use of the drug, discuss with his therapist the possibility of replacing Duromine with other OTC or prescription diet pills.
The reason why this slimming med is ineffective in some cases can be the tolerance to its anorexigenic effect.
It also rarely happens so that body does not respond to the drug action at all, and nothing can change that.
Since this drug contains a psychoactive substance Phentermine, its use requires a strict adherence to the recommended dosing regimen.
Prolonged use of anorexigenic drug in high doses, as well as its combination with alcohol are factors that may result in Duromine overdose and severe side effects.
Therefore, it is advised to abstain from alcohol-containing drinks and not to exceed the established dose on your own.
Sometimes, an overdose may occur because of accumulation of the active ingredient in the body.
Since the ative ingredient is metabolized mainly in the liver and excreted by the kidneys, violation of the functions of these organs may lead to a gradual accumulation of the psychoactive substance.
To avoid Duromine accumulation in the body and reduce the risk of overdose, obese patients with chronic kidney and liver diseases should take a low dose of this drug or switch to taking the drug every other day.
Another factor contributing to development of overdose can be drug interaction.
Clinical studies have shown that combined use of Duromine with other sympathomimetic agents or monoamine oxidase inhibitors enhances the therapeutic effect of this anorectic.
This combination leads to the development of hypertensive crisis and other complications involving the cardiovascular system
Symptoms of Duromine overdose are different.
Their frequency and severity depend mainly on the used dose, patient’s age and comorbidities.
Due to abuse of Duromine, symptoms often manifest in the form of hallucinations, rapid respiration, hyperreflexia, and panic states.
If you experience these symptoms, immediately stop using the drug.
However, abuse of this psychostimulant can also lead to such serious complications, as convulsions, central nervous system depression and coma.
Regardless of reasons for overdose with this drug, its symptoms require medical treatment.
Gastric lavage and use of activated charcoal are the first aid in case of the drug poisoning.
Oral use of tranquilizer Diazepam will help reduce the feeling of tension and fear and control severe symptoms of overdose.
When using Duromine, obese patients should adhere to the recommended dosing regimen and recommendations of the drug manufacturer.
This will contribute to an effective weight loss and will reduce the risk of possible Duromine overdose.
Duromine Side Effects
First of all, Duromine is a medication, which means it possesses both helpful effects and some side effects, too.
So, you should carefully read the list of possible side effects and allergic reactions.
When taking Duromine treatment course, you may feel weak or not rested.
In addition, such effects as sleeplessness, increased blood pressure, gastrointestinal tract issues, headache, and pain in chest or trouble breathing may also occur.
Since this drug is an appetite suppressant, you can also experience some stomach spasms.
However, all side effects are usually temporary and may not occur at all.
NB! Never use Duromine pills in dosage other than prescribed by your doctor.
This may cause overdose and further dangerous effects for your health.
Here’s the list of possible overdose symptoms:
- Convulsions (seizures)
- Fast Breathing
- Hostility with urge to attack
- Irregular blood pressure
- Irregular heartbeat
- Lightheadedness or Fainting
- Mental Depression, following a period of excitement
- Tremors, Trembling, or Shaking
- Overactive Reflexes
- Severe nausea, vomiting or diarrhea
- Stomach cramps
- Tiredness or Weakness.
Once you noticed some pain of any origin, high energy, panic or depression symptoms – it may mean that you are overdosed with Duromine pills.
Duromine short-term side effects
The drug may make you feel more awake than usual.
You may have trouble sleeping.
It can have some effects on the heart and some other more common symptoms, such as:
- Increased blood pressure
- Sense of well-being
Less common to rare symptoms:
- Blurred vision
- Change in sexual desire
- Dry mouth
- Irregular heartbeat
- Nausea or vomiting
- Skin rash or itching
- Stomach pain
- Unpleasant taste.
Duromine long-term side effects
There are some long-term side effects that are possible when someone takes Duromine.
The common effect is that there is possibility of dependence on the drug.
No studies were conducted to indicate this is possible, but it should be taken with care.
Can Duromine cause psychiatric side effects
Most often, the psychiatric side effects (PSES) that occur in the treatment of obesity with Duromine are associated with a spectrum of the drug pharmacological activity.
After the ingestion, Duromine enters into chemical interaction with sodium ions.
This leads to the decrease in sodium concentration.
The deficiency of sodium is the cause of such psychiatric side effects of Duromine, as irritability, nervousness and anxiety.
If you notice hyperirritability and hyperstimulation effect, it is recommended to reduce the dose or discontinue the drug.
To avoid insomnia and sleep problems, avoid taking this drug in the evening
Rare psychological side effects of Duromine, such as euphoria, accompanied by fatigue and depression, manifest in the drug overdose.
High doses of this weight loss drug can rarely cause hallucinations.
Patients with the following conditions should not use Duromine.
- An allergy to ingredients that are usually contained in Duromine
- Are pregnant, planning to become pregnant, or are breast-feeding
- Are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- Have allergies to medicines, foods, or other substances
- Have a brain or spinal cord disorder, hardening of the arteries, high blood pressure, diabetes, or high cholesterol or lipid levels.
Duromine drug interactions
Duromine may interact with drugs such as Dexfenfluramine, fenfluramine, furazolidone, or MAOIs (e.g., Phenelzine) and increase the risk of hypertensive crisis.
It can also have a negative reaction to Serotonin specific reuptake inhibitors (eg, Fluoxetine).
Guanadrel or Guanethidine can have their effectiveness reduced because of Duromine.
Thyroid hormones and alcohol may worsen Duromine side effects from the part of the CNS, as well as provoke dizziness and confusion.
Duromine is contraindicated in pregnant women
Preclinical animal studies on Duromine have shown that its use during pregnancy provides an expected benefit that is much smaller, than the potential risk to the embryo.
However, the results of this drug animal study that are available today, are not sufficient for a full determination of the “benefit/risk” ratio of Duromine for pregnant women and fetus.
By the scale of possible risks for the fetus, when used by pregnant women, this anorectic drug refers to:
- Category X – in the US
- Category B2 – in Australia and New Zealand.
Duromine is capable of indirectly affecting the cardiovascular system of women, contributing to blood vessels narrowing.
Thus, the use of Duromine during pregnancy may cause:
- violation of placental function
- violation of blood supply to the fetus
- decrease in the exchange of nutrients and gases between mother and child.
Duromine capsules have a prolonged therapeutic effect (approximately 10-14 hours).
When used by pregnant women, the risk of the drug penetration through the placenta increases due to this property of the drug
To avoid possible teratogenic or embryotoxic effects of this medication, women are advised to stop using these sliming pills as soon as they find out about their pregnancy.
Duromine: Safety Of Use During Lactation
The question on the feasibility of Duromine use after childbirth occurs in most women.
Pregnancy period provides favorable conditions for the development of adipose tissue.
Physiological changes (hormonal imbalance) occur in womren’s body and contribute to the excess fat gain.
Duromine is an adrenergic stimulant, which provides a significant psychostimulant action on the dopaminergic and noradrenergic systems.
No clinical data confirmed that Duromine passes into breast milk.
Only a probability exists that it may be excreted with the breast milk in very low doses.
Since the effect of drugs on a child’s development is unknown, mothers, who need to lose weight, should use mixed or artificial feeding.
Thus, women may use Duromine after delivery in two cases:
- if they find an alternative to breastfeeding
- if they use the weight loss drug after lactation period.
Duromine Storage Conditions
When storing Duromine you need to ensure that in is placed in a cool area where the temperature equals to or is below 30°C.
The tablets should be kept out of the reach of children.
They should also be kept in their packaging till they are ready to be used.
The information provided should not be used to substitute a doctor’s consultation. For full information, check out the patient’s leaflet and read it carefully. This information is provided for informational purpose only and should not be taken as a doctor’s advice.