Contrave

Contrave is a medication, which can help you get rid of a number of bad habits, such as excessive eating, smoking, as well as alcohol or drug addiction.

It is a potent medication, and you should know exactly how it works to ensure a safe treatment regimen, be it a weight loss campaign or fighting any of the mentioned habits.

If you already know some basic information about Contrave, feel free to get your answers to the most frequent questions, such as Contrave side effects, Contrave and alcohol and How to buy Contrave.

From Fat to Fit with Contrave: Burn Fat & Lose Weight

Belonging to a group of antidepressants, the medication is aimed at affecting the definite brain areas producing a positive action.

Containing the combination of Naltrexone and Bupropion in its composition, the preparation is powerful to decrease the appetite.

Besides, the treatment course is frequently recommended for addicted patients to eliminate the negative influence of alcohol or narcotics.

Additionally, the pharmaceutical is potent to curb food cravings and hunger.

In general, check the list of Contrave uses to realize you definitely need this cycle.

The medication:

  • Normalizes weight in overweight or obese patients suffering from related medical conditions;
  • Helps patients to quit smoking and avoid possible withdrawal effects;
  • Curbs hunger;
  • Decreases alcohol or narcotics impact on the organism.

It is important to remember that using Contrave for weight loss, one should combine the medication intake with constant exercises and a balanced diet.

Additionally, habit changes will be favorable for such consumers.

Irrespective of its classification, Contrave will not treat psychiatric conditions, mental disorders, depressions and similar issues.

What Is the Optimal Contrave Use?

The impact of Contrave over the body is significant, this is why it is a prescription medication, which requires doctor’s recommendations.

The combination of powerful active ingredients helps to significantly reduce the body mass index of severely obese patients.

Those people who are prescribed to start Conrave treatment course usually have one or more related health problems, such as diabetes, high blood pressure, overactive thyroid, high cholesterol and others.

The vital point in the medication cycle is that it should be taken with other weight management measures, such as exercising, dieting and habit modifications.

This will speed up the desirable results and eliminate possible risks of heart issues and stroke.

Taking this innovative remedy, follow doctor’s instruction to decrease potential harm and prevent side effects, as well as the following simple recommendations on the correct Contrave use:

  1. Take Contrave drugs as prescribed by your healthcare provider. Stick to the directions and never change them.
  2. Do not administer the medication for a longer time than necessary, or in bigger amounts.
  3. Never crush, break or chew the tablet – swallow it whole.
  4. Do not use more than 2 pills a day.
  5. Avoid combining Contrave with high-fat meals, since such a mix may cause seizures.
  6. Stop Contrave intake if you require any narcotic remedy.

Once you keep a track of all these points, you are likely to witness impressive results just within a couple of weeks.

Otherwise, the treatment is not appropriate for you, or the dose is too small.

To make sure you are ready to start Contrave weight loss treatment course, check the following points:

  • You have those devastating symptoms of condition complication;
  • You are ready to discuss your problems with a specialist;
  • You are open to talk about the history of your obesity and weigh loss process;
  • You agree to discuss and are ready to change some habits you have;
  • You acknowledge all the difficulties you may face during Contrave treatment course, though you are completely ready to work hard and overcome the issue.
  • If you say YES to all these points, you may be 100% sure that impressive weight reduction will not make you wait long.

Contrave Safety Concerns: Contraindications and Precautions

While Contrave serves an incredible remedy to manage weight, it frequently causes numerous complications due to wrong administration.

While the medication is available online without a prescription, the vast majority of customers neglects safety recommendations and, as a result, suffers from devastating side effects.

If you wish to take an advantage of Contrave treatment, consult your healthcare provider or medical professional to check whether the drug is safe for you.

Provide the specialist with the full information concerning your health.

Contrave contraindications combine the contraindications list to Bupropion and Naltrexone (Contrave pills active ingredients).

It is contraindicated in patients with diagnosed hypersensitivity to Bupropion and Naltrexone.

Contrave is contraindicated in pediatric (up to 18 y.o.) and elderly (over 65 years) age.

Obese and overweight patients with severe liver and kidney failure should not take Contrave.

Patients with renal and (or) hepatic insufficiency should use other weight loss drugs.

Bupropion (one of Contrave active ingredients) is contraindicated in obese patients with epilepsy, a history of seizures, Parkinson’s disease and Alzheimer’s disease.

Therefore, it is contraindicated in people with these pathologies.

Naltrexone (another active ingredient of Contrave) is contraindicated in patients with hemodyscrasia.

So, it is important to make sure that you have no hemodyscrasia.

Moreover, Contrave is contraindicated in:

  • Oncology diseases
  • Autoimmune diseases.

This is not a complete list of Contrave drug contraindications.

Check out the patient leaflet or ask your doctor about any concerns that you have.

Who should not take Contrave?

People, who have:

  • Uncontrolled blood pressure
  • Eating disorders
  • Seizures
  • Kidney failure

Additionally, inform your doctor if you have been using MAO inhibitors in the past 14 days, or any narcotic medicines, as well as seizure drugs.

Contrave can interact with these and other prescription and over-the-counter remedies and lead to severe complications.

Additionally, mention the following health disorders for your doctor to prescribe an appropriate Contrave dose and intake periodicity:

  • Narrow-angle glaucoma;
  • Diabetes of any type;
  • High blood pressure, heart diseases, a history of heart attack or stroke;
  • Kidney and liver disorders;
  • Depression, suicidal thoughts, bipolar disorders, and other mental illnesses;
  • Heart injury;
  • Brain infections or tumors and others.

Never pass the drug to other people with similar symptoms without doctor’s permission.

Just like all CNS-affecting drugs, Contrave is contraindicated during pregnancy.

Its use in pregnancy is possible only if the potential benefit to the mother outweighs the potential risk to fetus.

Given that the use of the drug during pregnancy increases the risk of congenital abnormalities in fetus, pregnant women should refrain from using Contrave.

Women of reproductive age are recommended to use reliable contraception while using Contrave.

When choosing oral contraceptives, you should pay attention not only to their effectiveness, but also to side effects.

Women of childbearing age should choose oral contraceptive pills, which do not contribute to weight gain.

Also before using Contrave diet pills, woman should make sure she isn’t pregnant.

Only after that obese or overweight woman can start taking oral contraceptive pills and Contrave weight loss drug.

Clinical studies have shown that Bupropion and Naltrexone active ingredients penetrate into breast milk.

Given that Bupropion and Naltrexone have a carcinogenic effect, they can create a potential threat to the overall health of a newborn.

Contrave Misuse and side effects

If you wish to buy Contrave, you should be aware of all the possible side effects, caused by the medication misuse.

Follow the given recommendations to avoid all the potential dangers, including:

  • Severe allergic reactions (hives, swallowing, itching, breathing problems, etc.);
  • Confusions, fainting, dizziness;
  • Chest pain, uneven heart beat;
  • Joint and muscle pain;
  • Hallucinations, anxiety, agitation;
  • Depression, panic attacks;
  • Convulsions, seizures;
  • Nausea, vomiting, appetite loss, stomach disorders and others.

People, who are hypersensitive to the active ingredients or excipients of the drug, must never use it. Contrave contains more than 10 excipients. You can find the full list of excipients in the Contrave package insert.

Contrave Drug Interactions

Just to remind you…

Contrave diet pills contain two pharmaceutical ingredients – Bupropion Hydrochloride (HCL) and Naltrexone HCL.

Combination of these two substances allows increasing efficiency of physical exercises and low-calorie diets.

Contrave drug interactions are identical to drug interactions of Bupropion and Naltrexone active substances.

Contrave may affect pharmacological activity of certain drugs.

Other drugs may also affect Contrave pharmacological properties.

Possible side effects of Bupropion are change in behavior, anxiety, insomnia and high physical activity.

Naltrexone can cause liver damage or hepatitis. Do not take Contrave in severe liver disease.

The symptoms of liver dysfunction are:

  • Fatigue
  • Dark urine
  • Yellow eyes.

Contrave slimming pills are intended for adult people, whose obesity or overweight is accompanied with some risk factors, for instance, diabetes.

If you need to use other prescribed or over the counter medications along with Contrave, please consult the doctor.

Some medications, like antidepressants, may cause CNS side effects when combined with Contrave.

As you see, contrave interaction with other drugs can cause serious side effects.

Therefore, before using Contrave, inform your doctor about all the drugs taken.

If the doctor recommends to use Contrave in combination with other drugs, it is necessary to comply with the dosing regimen of all designated drugs.

Daily dose of Contrave or other taken drugs can be adjusted only after consulting a physician.

Bupropion may affect pharmacokinetic properties of MAO inhibitors (Carbex, Marplan, Parnate).

Therefore, between taking Contrave and MAO inhibitors a break of at least 14 days is recommended.

Bupropion active ingredient is metabolized in liver.

Therefore, those who take liver enzymes affecting drugs (Cyclophosphamide, Clopidogrel, Orphenadrine) – should use Contrave with caution.

Furthermore, Bupropion may increase plasma concentrations:

  • SSRIs (Citalopram, Escitalopram),
    Tricyclic antidepressants (Amitriptyline, Nortriptyline, Imipramine),
    Antiarrhythmic drugs (Amiodarone).
  • Increasing peak concentrations of these drugs in plasma, Contrave may enhance their activity and thereby contribute to seizures. That is why their simultaneous use with Contrave is contraindicated.

Drinking alcohol while using Contrave may increase the risk of side effects (convulsions, anxiety, depression, hallucinations, and paranoia).

Simultaneous Contrave use with antipsychotics can cause atony and sleepiness.

Therefore, it is recommended to refrain from antipsychotics (including Thioridazine) during Contrave treatment.

Therapeutic effects of opioid drugs for treatment of colds and coughs, (containing Dextromethorphan, Codeine) can be reduced while taking Naltrexone.

Therefore, during the obesity treatment with Contrave, opioid drugs are contraindicated.

This might be not a complete list of Contrave drug interactions.

Before complementing obesity therapy with any drugs, it is advised to consult the doctor or pharmacist.

Dosage forms and strengths of Contrave

Contrave appetite suppressant is available in extended-release tablets.

The dosage of biconvex blue Contrave pills is 8mg of Naltrexone HCL and 90mg of Bupropion HCL.

Contrave weight loss tablets are engraved with “NB-890” on one side.

It is noteworthy that breakage of a tablet can change the therapeutic effect of medications.

Therefore, you must not chew or crash the tablets.

How do I take Contrave?

Before you start the treatment of overweight or obesity, you need to find out the dosage schedule of Contrave.

So, you can read the instructions for Contrave or read this review further.

Contrave slimming pills can be used in a long-term anti-obesity treatment.

At the beginning of anti-obesity therapy, the recommended Contrave dosage is 1 pill per day.

To reduce appetite for most of the day, you should better take the drug in the morning.

You can gradually increase the daily dose of Contrave. It is necessary to increase the dose by one more pill every 7 days.

At the beginning of week of anti-obesity therapy, an optimal dose is achieved – 2 Contrave tablets, twice daily.

Overdosage

During clinical trials, the maximum daily dose of Contrave was 50mg Naltrexone and 400mg Bupropion.

It has been established that Contrave overdosage symptoms could be rapid heartbeat, arrhythmia and temporary loss of consciousness.

To avoid side effects and overdosage, you must never take more than 4 Contrave tablets a day.

If Contrave overdosage symptoms occur, a gastric lavage and symptomatic treatment are recommended.

Contrave and Alcohol

Contrave is one of a few combined drugs, used for treatment of overweight or obesity. If you want Contrave weight loss pills to work effectively, you need to follow some simple rules and recommendations.

Contrave drug stimulates the separate parts of the brain, suppressing the appetite. As you probably know, alcohol affects the brain functions and may even cause short- or long-term mental changes.

Everybody knows that alcohol must never be combined with most medications of all pharmaceutical groups. Consumption of Contrave and alcohol may cause various neuropsychological events that will hinder your anti-obesity treatment. Clinical trials have demonstrated that when using Contrave, obese people become less tolerant to alcohol sometimes.

Alcohol is not contraindicated during Contrave diet pills use. However, if you want your therapy of overweight or obesity to be successful, you need to limit the consumption or completely give up drinks containing alcohol.

Contrave diet drug is contraindicated for people, addicted to alcohol, or those who suddenly quit drinking it. The drug is also contraindicated for people, who undergo anti-alcoholic, opioid and some other kinds of addiction therapy.

A combined use of Contrave and alcohol is allowed, yet is not recommended by nutritionists. Alcohol does not only affect the brain work, but also contains a large number of calories.

Besides, alcohol enhances appetite, hence can cause an uncontrolled food consumption. The price of Contrave diet pills remains high, that is why it would be a pity to lose the weight loss results achieved within a week in one day.

Contrave FDA

Contrave is a new combined drug, used as a supplement to weight loss program. Contrave is a good variant for a stable weight loss in people, who cannot lose weight by means of diets and increased physical activity.

Overweight people from North America have gained a great opportunity to buy Contrave recently. Contrave drug for anti-obesity treatment got the FDA «approved» status in September 10, 2014. After that, the manufacturing company started to produce this drug in great quantities and supply it to the USA pharmaceutical market.

The owner of Contrave marketing authorization in the USA is Takeda Company – one of the leaders of the pharmaceutical industry in Japan and Asia. Contrave is produced by Orexigen Therapeutics.

The FDA approved Contrave in film-coated tablets for oral intake. Round-shaped, biconvex blue Contrave tablets have «NB-890» imprint on one side. Tablets consist of several layers, providing claimed dissolution and absorption of the active substance.

Contrave weight loss pills were approved by the FDA after several large-scale clinical trials. These trials involved several thousands of people with different severity of obesity and various comorbidities (including diabetes and hypertension).

During all these trials, Contrave group of patients lost more weight than the group, using placebo. The FDA consulting group reviewed the results of Contrave studies and concluded that this drug had caused a clinically significant weight loss.

An additional information on clinical trials of Contrave diet pills is presented on the FDA official website. Both medical specialists and ordinary consumers might need Contrave FDA label and Contrave FDA briefing document.

Today, Contrave is the only medication of such kind that was approved by the FDA. The price of this medication remains high. Probably, in the future, some companies will release Contrave generic drugs that will be cheaper than the original drug.

Contrave trials

Contrave is a new drug to cure people diagnosed with overweight or obesity. Contrave combined centrally acting drug reduces appetite, so it is used as a part of a plan to keep the body weight under control.

Contrave drug was approved by the FDA (USA) in 2014. Similar drug – Mysimba was approved by the EMA (Europe) in 2015. It is possible that overweight people from other countries will have a chance to buy Contrave or Mysimba diet pills in 2016-2017.

Before the drug appears on the pharmaceutical market, it must undergo large-scale clinical trials. The same thing with Contrave. Thousands of people who achieved clinically significant weight loss participated in clinical trials of Contrave diet pills.

Contrave is a trademark of Orexigen Therapeutics – a biopharmaceutical company, specializing in obesity treatment. This company developed and conducted clinical trials of Contrave (Bupropion Hydrochloride and Naltrexone Hydrochloride).

The North American distributor of Contrave is Takeda. This company is engaged in commercial promotion and post-marketing trials of Contrave drug.

The placebo-controlled clinical trials of Contrave for anti-obesity treatment in adults took 56 weeks. To Contrave clinical trials were complete; there were involved men and women of different age groups suffering from hypertension, coronary artery disease and severe obesity.

Clinical trials have revealed that best results with Contrave drug were achieved by people, who had been taking two pills, twice daily (in the morning and in the evening). However, to reduce the risk of Contrave side effects, the anti-obesity therapy should be initiated with one pill every morning.

People, participating in Contrave trials, sometimes experienced side effects. The most common side effects of Contrave were – nausea, vomiting, constipation, stomachache and dry mouth.

Contrave trials have also shown that in some categories of overweight patients, side effects were more frequent and severe than in others. Therefore, people with reduced function of liver, kidneys or heart, should use Contrave slimming pills with caution.

Usually, severe diseases of internal organs are in the list of Contrave contraindications for use. In addition, during Contrave trials, scientists have found that patients should minimize or quit drinking alcohol.

Unfortunately, the clinical trials do not take into account the Contrave price, which is still quite high these days. In order to stop world epidemic of obesity, we need both effective and cheap diet pills. If people start buying Contrave more often, the price on these pills will be decreasing.

Contrave Manufacturers

Orexigen Therapeutic is a biopharmaceutical company that develops drugs for obesity treatment. Orexigen Company developed a combined weight loss drug Contrave. While developing this drug, the manufacturer used FDA-approved active substances Bupropion and Naltrexone.

Phase III of safety and efficacy clinical trials of the new Contrave drug was completed at the end of 2013. Results of the trials were submitted for study to FDA. It is assumed that the FDA will publish safety and efficacy data of Contrave combined drug in June 2014.

The FDA previously reported that if the interim study confirms Contrave safety, this weight loss drug would be sold at the US pharmacies already in 2015-2016.

According to preliminary data, Contrave does not cause serious cardiovascular abnormalities or other side effects, potentially threatening human health. Therefore, in 2015 or 2016 Contrave will be able to successfully compete with other appetite suppressants available at the U.S. pharmaceutical market.

Buy Contrave

If you live outside the USA and cannot buy Contrave tablets, you may order other weight loss drugs, for instance, Phentermine.

You can buy such medications under the brand name Adipex and Duromine.

You can buy Contrave weight loss drug in a plastic bottle, protecting the drug from moisture and external factors.

Contrave must be stored in the original package, away of heat, light and moisture. Keep the drug out of reach of children and pets.

Dr. Kathleen Hallinan about Contrave